The DNA packed inside every human cell contains instructions for life, written in billions of letters of genetic code. Every time a cell divides, the complete code, divided among 46 chromosomes, must ...

Bacteriophages deploy streamlined yet robust strategies to replicate their DNA within host cells. Replication typically initiates at defined viral origins recognised by phage-encoded initiator ...

Professor Norikazu Ichihashi and his colleagues at the University of Tokyo have successfully induced gene expression from a DNA, characteristic of all life, and evolution through continuous ...

理化学研究所（理研）生命機能科学研究センター発生エピジェネティクス研究チームの平谷伊智朗チームリーダー、高橋沙央里基礎科学特別研究員、三浦尚研究員、三重大学大学院医学系研究科の竹林慎一郎講師、柴田隆豊大学院生（研究当時）らの共同 ...

A new study from Karolinska Institutet, published in Nature Communications, reveals that cyclin-dependent kinases (CDK) promote DNA replication licensing in human cells by relieving inhibitory signals ...

CDT1 inhibits the helicase activity of the MCM complex, thereby suppressing nascent strand synthesis in DNA replication in cultured human cells. This action results in fork collapse and DNA damage, ...

The MCM helicase is broadly bound across the genome, and its phosphorylation is antagonistically regulated by the kinase DDK and the phosphatase RIF1–PP1. TRESLIN–MTBP recognises the phosphorylated ...

When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication process can cause alterations in genomic DNA, promoting cellular ageing, cancer, ...

The human genome consists of 3 billion base pairs, and when a cell divides, it takes about seven hours to complete making a copy of its DNA. That's almost 120,000 base pairs per second. At that ...

When it comes to cancer, tumor suppressor genes are usually thought of as the "good guys." These genes make proteins that ...

JSTのERATO審良自然免疫プロジェクトとして、審良 静男（大阪大学免疫学フロンティア研究センター拠点長）、石井 健（同微生物病研究所難治感染症対策研究センター准教授）らは、「DNAワクチン」とよばれる新型ワクチンの作用メカニズムを ...